Interoperability Optimization and Service Enhancement in Vehicle Onboard Infortainment Systems

This paper presents an overview on optimizing interoperability between different applications for enhanced return-on-investment through utilization of business intelligence in conjunction with prognostics and health management methodology. Such implementation is particularly suitable for deployment in mass-produced vehicle onboard diagnostics system

Environmental Pollution and Chronic Disease Management – A Prognostics Approach

No abstract available

A Regression Analysis on the Macroeconomic Variables Affecting Taiwan’s Export Value to the US before and after 2008 Financial Crisis

The booming of international trade since 1980 has resulted in the sharp economic growth of Taiwan. It is therefore important to understand the influential factors and their impacts on Taiwan’s international trade and export. This research adopts multiple regression method to identify the respective influential macroeconomic variables affecting the export values of Taiwan to the U.S. before and after 2008 financial crisis. It also analyzes the correlations among these macroeconomic variables. The results of this research indicate that, the first lag period of: (1) Taiwan industrial production index, (2) exchange rate of U.S. dollar to New Taiwan dollar, (3) US Interbank real call loan rate, and (4) U.S. industrial production index are influential macroeconomic variables affecting export values of Taiwan to the U.S. before 2008 financial crisis. After 2008 financial crisis, the influential macroeconomic factors are the first lag period of (1) exchange rate of U.S. dollar to New Taiwan dollar, (2) Taiwan’s industrial production index, (3) Mainland China’s consumer price index yearly increment, and (4) Taiwan’s wholesale price index yearly increment (excluding service)

Do Girls and Boys Perceive Themselves as Equally Engaged in School? The Results of an International Study from 12 Countries

This study examined gender differences in student engagement and academic performance in school. Participants included 3420 students (7th, 8th, and 9th graders) from Austria, Canada, China, Cyprus, Estonia, Greece, Malta, Portugal, Romania, South Korea, the United Kingdom, and the United States. The results indicated that, compared to boys, girls reported higher levels of engagement in school andwere rated higher by their teachers in academic performance. Student engagement accounted for gender differences in academic performance, but gender did not moderate the associations among student engagement, academic performance, or contextual supports. Analysis of multiple-group structural equation modeling revealed that perceptions of teacher support and parent support, but not peer support, were related indirectly to academic performance through student engagement. This partial mediation model was invariant across gender. The findings from this study enhance the understanding about the contextual and personal factors associated with girls' and boys' academic performance around the world

Textile Waste Fiber-Reinforced Mortar: performance evaluation

Trabalho apresentado em 1st International AFRICA Sustainable Waste Management Conference, 23-25 July 2012, Lobito, AngolaN/

Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma.

PurposeTumors with low frequencies of checkpoint positive tumor-infiltrating lymphocytes (cpTIL) have a low likelihood of response to PD-1 blockade. We conducted a prospective multicenter phase II trial of intratumoral plasmid IL-12 (tavokinogene telseplasmid; "tavo") electroporation combined with pembrolizumab in patients with advanced melanoma with low frequencies of checkpoint positive cytotoxic lymphocytes (cpCTL).Patients and methodsTavo was administered intratumorally days 1, 5, and 8 every 6 weeks while pembrolizumab (200 mg, i.v.) was administered every 3 weeks. The primary endpoint was objective response rate (ORR) by RECIST, secondary endpoints included duration of response, overall survival and progression-free survival. Toxicity was evaluated by the CTCAE v4. Extensive correlative analysis was done.ResultsThe combination of tavo and pembrolizumab was well tolerated with adverse events similar to those previously reported with pembrolizumab alone. Patients had a 41% ORR (n = 22, RECIST 1.1) with 36% complete responses. Correlative analysis showed that the combination enhanced immune infiltration and sustained the IL-12/IFNγ feed-forward cycle, driving intratumoral cross-presenting dendritic cell subsets with increased TILs, emerging T cell receptor clones and, ultimately, systemic cellular immune responses.ConclusionsThe combination of tavo and pembrolizumab was associated with a higher than expected response rate in this poorly immunogenic population. No new or unexpected toxicities were observed. Correlative analysis showed T cell infiltration with enhanced immunity paralleling the clinical activity in low cpCTL tumors